In patients with chronic heart failure, patients in Q1 (−1.64 [−6.3 to −0.9] g/dL/year) with changes in Hb divided into quartile had a greater risk of mortality, hospitalization than patients in Q3 (0.14 [−0.1 to 0.4] g/dL/year) [17]. This evidence concerns the gene GSTM1 and congestive heart failure.