The biological processes, cellular components, and molecular activities of DEGs that were most dramatically enriched in psoriasis mice after ESW intervention included the intrinsic apoptotic signaling pathway in reaction to endoplasmic reticulum stress, positively regulating microtubule nucleation, regulation of microtubule nucleation, respirasome, zona pellucida receptor complex, and NADH dehydrogenase activity (Fig 5). The gene discussed is ENSG00000254051; the disease is psoriasis.