The results indicated that P. clypearia may affect the energy metabolism, cell growth and apoptosis by regulating genes such as Hspa1a, Hspa1b, mt-Nd4l, mt-Nd5, mt-Nd6, Bcl-2, Asns, Trib3, GzmA, CTSG, etc, thereby mitigating psoriasis-related inflammation. The gene discussed is HSPA1B; the disease is psoriasis.