CRBN and acute lymphoblastic leukemia: We further investigated the LMO2 degradation in natural LMO2 expression settings (i.e. T-ALL lines) using a lentivirus that conditionally expresses anti-LMO2 iDAb VH576 fused to CRBN E3 ligase (designated TLCV2-iDAb-CRBN) via a doxycycline-inducible promoter (TLCV2; Barger et al., 2019).