For instance, S-phase kinase-associated protein-2 (Skp2), a member of F-box family protein and highly up-regulated in many cancers, a crucial component of the SCF (Skp1-Cullin-F box) substrate recognition complex, is reported to promote the EMT through controlling the expression of several EMT marker proteins in multiple cancers [19–21]. This evidence concerns the gene CACUL1 and cancer.