This prospective study assessed the trajectory of 1,5-AG, 1,5-AG/HOMA-IR and 1,5-AG/BMI during pregnancy up to 1-year postpartum, their association with indices of insulin secretion/resistance and whether these indices can predict glucose intolerance (prediabetes and diabetes) at 1-year postpartum in women with GDM. This evidence concerns the gene INS and prediabetes syndrome.