In the models for cognitive decline, significantly associated variables included the number of APOE ε4 risk alleles (fully adjusted model, 1 versus 0, p = 0.012; 2 versus 0, p < 0.001), and primary versus higher education in models 2-4 (model 4, p = 0.030) (Supplemental Table 1). This evidence concerns the gene APOE and Mental deterioration.