SDH‐deficient RCC is characterized by germline mutations of any of the four SDH genes (SDHA, SDHB, SDHC, and SDHD) and is associated with an autosomal dominant hereditary syndrome that also includes a constellation of other tumours, including phaeochromocytoma/paraganglioma, distinct gastric gastrointestinal stromal tumour, and pituitary adenoma.70, 71, 72, 73, 74, 75. This evidence concerns the gene SDHA and renal cell carcinoma.