The remaining IHC profile of ALK‐rearranged RCC is variable, but includes reactivity for PAX8 and vimentin, and retained FH and INI1, the last two being useful in differentiating it from FH‐deficient RCC and SMARCB1‐deficient renal medullary carcinoma, respectively. The gene discussed is ALK; the disease is renal cell carcinoma.