On microscopy, SDH‐deficient RCC typically shows sheet‐like or compact nested growth of bland cuboidal cells with low‐grade nuclei, eosinophilic cytoplasm and variable intracytoplasmic vacuoles (thought to represent abnormal giant mitochondria)77 scattered microcysts and entrapped non‐neoplastic tubules (Figure 4B,C).64, 65, 78. Here, SDHB is linked to renal cell carcinoma.