Despite the commonality of TSC/MTOR mutations, the principal component analysis based on differentially expressed genes showed that EVT, LOT, and ESC RCC were segregated from each other and were distinct from other renal tumour types20 EVT also lacked complete losses or gains of chromosomes, but a loss of the wild‐type allele on chromosome 1 (where MTOR resides) has been found17, 44, 48 as well as isolated losses of chromosomes 19p, 16p11, and 7q3116, 44. Here, TSC1 is linked to renal cell carcinoma.