PRKAR1A variants are commonly the sole pathogenic genomic finding in clinically benign LCCSCTs without aggressive histopathologic features, whereas clinically malignant tumours tend to harbour additional alterations, including mutations, chromosomal aneuploidies and homozygous deletion of tumour suppressors (e.g., CDKN1B/2A/2B), among others.67, 77. The gene discussed is PRKAR1A; the disease is neoplasm.