Epithelial cells in region 11 were enriched for the expression of mesenchymal genes, including Vimentin (Mendez et al., 2010) (Vim, FDR = 7.4 10–245, one-sided Fisher’s exact test), Prox1 (Lu et al., 2012) (FDR = 3.7 10–153), and Sox11 (Oliemuller et al., 2020) (FDR = 7.7 10–224) (Figure 5—figure supplement 1F), as well as for EMT signatures from a mouse model of lung adenocarcinoma (Marjanovic et al., 2020) (FDR = 1.5 10–142, two-sided Mann-Whitney U test) and from human head and neck squamous cell carcinoma tumors (Puram et al., 2017) (FDR = 6.9 10–55, two-sided Mann-Whitney U test). The gene discussed is PROX1; the disease is lung adenocarcinoma.