This resulted in both an increase in cells of existing populations (e.g. some T cell subsets [TNK05 (GdT/Il17+), TNK06 (Treg)]) and emergence of new dysplasia-associated cells (e.g. granulocytes [Gran01, Gran02] and monocytes [Mono02, Mono03]) mirroring observations in human CRC (Pelka et al., 2021), breast cancer (Hagerling et al., 2019), and non-small cell lung cancer (Arenberg et al., 2000; Figure 1C and D, Figure 1—figure supplement 1D and E and Figure 1—figure supplement 2A–C). This evidence concerns the gene IL17A and colorectal carcinoma.