These include Sparc, expressed mainly by endothelial cells and fibroblasts in our data, known to promote CRC invasion (Drev et al., 2019); and Ctss, a peptidase expressed by T cells and monocytes-macrophages that promotes CRC neovascularization and tumor growth (Burden et al., 2009). The gene discussed is LAP3; the disease is colorectal carcinoma.