CRP and dental caries: As shown in Figure 3 and Table S3, CRP, leukocyte, neutrophil and lymphocyte were significantly mediated the association between vitamin B12 and dental caries risk (proportion mediated (PM), 0.91%, P = 0.038; PM, 0.958%, P = 0.046; PM, 1.16%, P = 0.008; PM, 1.02%, P = 0.024).