Gaining an understanding of the order of events and the structural dynamics involved in this process is important not only for understanding the fundamental basis of energy transduction by motor enzymes but also for guiding the design of drugs to alter the force-generating capacity of myosin to treat diseases such as heart failure (Hei et al., 2024; Planelles-Herrero et al., 2017; Woody et al., 2018). The gene discussed is MYH14; the disease is heart failure.