FA: Fanconi anemia, HR: homologous recombination, MMR: mismatch repair, pks: polyketide synthase, E.Coli: Escherichia coli, CRC: colorectal cancer, SBS88: single base substitution signature 88, APC: Adenomatous Polyposis Coli, TP53: tumor protein P53, SASP: senescence-associated secretory phenotype, NOD2: nucleotide-binding oligomerization domain-containing protein 2, ATG16L1: autophagy related 16 like 1, CoPEC: colibactin-producing Escherichia coli, FUT2: Fucosyltransferase 2, IBD: inflammatory bowel disease. The gene discussed is ARAF; the disease is colorectal cancer.