AR and posterior cortical atrophy: Parallel metagenomic analyses in PCa patients undergoing enzalutamide or abiraterone treatment have revealed enrichment of Ruminococcus, Bacteroides, and Prevotella species harboring CYP450 and steroid dehydrogenase genes, corroborating the concept of a “microbial androgen factory” that perpetuates AR activation despite pharmacologic suppression (34, 78).