Next, we evaluated the three genes’ potential for diagnosis, SPP1, LYZ, and MCM5, in the RA test set data (GSE55235, GSE55457, and GSE77298) and validation set (GSE89408) as well as the cervical cancer test data sets (TCGA and GTEx) and validation set (GSE63514). This evidence concerns the gene LYZ and rheumatoid arthritis.