GO and KEGG enrichment of the differentially down-regulated genes revealed their associations with the following: negative regulation of immunoglobulin mediated immune response, negative regulation of B cell mediated immunity, positive regulation of the MAPK cascade, regulation of cell growth, DNA binding transcription repressor activity, signaling pathways regulating stem cell pluripotency, JAK–STAT signaling pathway, and cGMP-PKG signaling pathway; chemical pathways involving estrogen, choline in cancer, amphetamine dependency, cholesterol, and pyruvate metabolism. The gene discussed is SOAT1; the disease is cancer.