The analysis based on single cell transcriptome data revealed that the SPP1 signaling pathway was significantly enhanced in cervical cancer patients and was Myeloid cells and epithelial cells; lastly, it was found that the expression levels of SPP1, LYZ, and MCM5 were significantly higher in clinical tissue samples from patients with RA combined with cervical cancer when analyzed immunohistochemically. Here, LYZ is linked to rheumatoid arthritis.