In particular, amyloid PET imaging has reaffirmed the relatively diffuse and stereotypical pattern of Aβ plaques in those with AD, and tau PET has reinforced that the dominant pattern of pathologic spread is defined by Braak staging with tau pathology starting in the transentorhinal cortex and hippocampus prior to spreading to additional limbic and temporal neocortical regions and then to parietal, frontal, and occipital cortex (Braak & Braak, 1991; Brier et al., 2016; Klunk et al., 2004; Schwarz et al., 2016). Here, MAPT is linked to Alzheimer disease.