This study aimed to investigate the relationship between the expression levels of Leukocyte Immunoglobulin-Like Receptor Subfamily B2 (LILRB2) and Apurinic/Apyrimidinic Endonuclease 1 (APE1) and the pathological characteristics in colorectal cancer (CRC) patients, as well as their predictive value for prognosis. The gene discussed is LILRB2; the disease is colorectal cancer.