EGFR and cancer: Herein, we explore an alternative approach to constructing bispecific peptide-based agents, which involves the use of DNA as a ruler-like molecular linker (Fig. 1).27–45 Short, synthetic DNA strands can serve as programmable, biocompatible scaffolds to spatially organize and connect peptide ligands targeting EGFR and MET.46 The nanometer-scale control over the distance and orientation between the two peptides presented on self-assembled complexes enables a convenient optimization for cooperative binding to receptor pairs on the cancer cell surface.