TARDBP and amyotrophic lateral sclerosis: For example, RNA-binding proteins such as TDP-43 and FUS normally form dynamic liquid droplets, but in neurodegenerative conditions like amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), they accumulate as insoluble fibrillar inclusions (Patel et al., 2015; Carey and Guo, 2022).