SIRT2 and Huntington disease: Pharmacological induction of autophagy by rapamycin, rilmenidine, SMERs, and felodipine, amongst others improves progression in HD animal models; inhibition of PARP1 or SIRT2 show neuroprotective effects in HD mouse and Drosophila models; NAD+ boosting by NAM and niacin, are protective in HD animal models with further ongoing clinical trial with NR in HD patients (NCT06853743)