Pharmacological autophagy inducers, such as carbamazepine, trehalose, spermidine, and rapamycin or its analog temsirolimus, amongst others, have been shown to enhance the clearance of Aβ plaques and tau tangles, and ameliorate disease phenotypes including cognitive deficits, in various AD mouse models (Caccamo et al., 2010; Rodríguez-Navarro et al., 2010; Spilman et al., 2010; Majumder et al., 2011; Schaeffer et al., 2012; Du et al., 2013; Li et al., 2013; Ozcelik et al., 2013; Jiang et al., 2014a; 2014b; Portbury et al., 2017; Freitag et al., 2022). The gene discussed is MAPT; the disease is Alzheimer disease.