Pharmacological induction of autophagy by rapamycin, rilmenidine, SMERs, and felodipine, amongst others improves progression in HD animal models; inhibition of PARP1 or SIRT2 show neuroprotective effects in HD mouse and Drosophila models; NAD+ boosting by NAM and niacin, are protective in HD animal models with further ongoing clinical trial with NR in HD patients (NCT06853743). This evidence concerns the gene PARP1 and Huntington disease.