Additionally, overexpression of SIRT1 or SIRT5, genetic mutation of Parp, or inhibition of PARP1 is protective in cell and animal models of AD (Qin et al., 2006; Min et al., 2010; Abeti et al., 2011; Martire et al., 2016; Wu et al., 2021; Yu et al., 2021). Here, SIRT5 is linked to Alzheimer disease.