Supplementation with NAD+ precursors, such as NAM, NR or NMN, restores NAD+ levels and also prevents neurodegenerative pathology and cognitive decline in AD mouse models (Green et al., 2008; Gong et al., 2013; Liu D. et al., 2013; Yao et al., 2017; Hou et al., 2018; 2021; Rehman et al., 2021; Ma et al., 2024; Xiong et al., 2024). This evidence concerns the gene NTS and Alzheimer disease.