ACHE and Cognitive impairment: However, the disease burden of Parkinson’s disease depends not only on motor symptoms but also, to a large extent, on non-motor symptoms (e.g. impairments in cognition or dementia).2 Currently, effective treatments for non-motor symptoms, such as cognitive deficits, are limited to cognitive3 and physical training4,5 in mild cognitive impairment and rivastigmine,6 an acetylcholinesterase inhibitor in Parkinson’s disease dementia.