In glioblastoma, KAT2A/α-KGDH complex-driven histone H3 succinylation at K79 activates oncogenic transcription (36), while in hepatocellular carcinoma, OXCT1-succinylated LACTB reinforces mitochondrial metabolism to support tumor progression (10). The gene discussed is KAT2A; the disease is glioblastoma.