In this sense, 0.1 mM acetic acid decreases IL-6 and TNF-alpha production in the liver of mice with cecal ligation and puncture-induced sepsis, whereas 20 mM acetic acid stimulates IL-6, IL-8, and IL-1 beta synthesis in peripheral blood mononuclear cells (PBMCs) from healthy donors (117, 118). The gene discussed is IL6; the disease is Sepsis.