EGF and neoplasm: By considering the alteration of ECM in relation to its abundance, tumour cells are shown to orchestrate the recruitment of stromal cells that produce various pro-fibrotic growth factors and inflammatory factors such as TGF-α, TGF-β, fibroblast growth factor (FGF)-2, platelet-derived growth factor (PDGF), and epidermal growth factor (EGF) (54).