MAF and inflammatory bowel disease: Previous research has revealed that Notch/STAT3-induced c-Maf-dependent IL-10 signaling pathways are disrupted in effector CD4+ T cells, which leads to reduced IL-10 production and increased pro-inflammatory Th1 and Th17 cells, resulting in increased infiltration of granulocytes and myeloid cells, and worsening tissue damage in IBD (85–87).