LRRK2 mutations (such as G2019S) promote mitochondrial fission in microglia by enhancing kinase activity, releasing mtROS and other factors to activate the NLRP3 inflammasome, exacerbating neuroinflammation in PD, and their regulation of mitochondrial dynamics has potential associations with ferroptosis (124). Here, LRRK2 is linked to Parkinson disease.