ACSL4 and Parkinson disease: In LUHMES cell models of PD, RSL3 induces ferroptosis, while ACSL4 inhibitors (such as troglitazone), ALOX15/15B inhibitors (such as PD 146176, baicalein), and siRNAs targeting ACSL4, ALOX15, and ALOX15B all effectively inhibit ferroptosis and protect cells (70).