Unlike the specific, targeted action of β-glucans, the diverse structural motifs in APS can interact with a broader repertoire of immune receptors (e.g., TLR2, TLR4, MR), thereby enabling a “multi-pronged” mode of action that may result in a more comprehensive and balanced immunomodulatory outcome. This evidence concerns the gene NR3C2 and autoimmune polyendocrinopathy.