the organ index of spleen and thymus increased, Elevated levels of cytokines IL-2, IL-6, and TNF - α in mouse serum, The proportion of CD4+T cells and CD8+T cells in peripheral blood of mice increases, Increased expression of p53 in tumor cells upregulation of Bax/Bcl-2 ratio in tumor cells,. The gene discussed is TNF; the disease is neoplasm.