CLPB and Decreased total neutrophil count: Heterozygous CLPB alterations were located not only in the ATP domain, e.g., p.Arg598Cys, which has been described to affect mitochondrial function and induce apoptosis leading to neutropenia (28, 29), but also in the ankyrin and D2 domains, which turned out to affect CLPB oligomerization (data not shown).