Autoimmune attacks may engage, as dominant effectors, CD8+ T cells (e.g. T1D, vitiligo, AA (6, 92, 93)), CD4+ T cells (e.g. MS, SLE, RA, IBD, EAE, autoimmune thyroid diseases, psoriasis (94)), NK cells (e.g. AA, SLE, RA, MS, psoriasis, T1D (95, 96)) or autoantibodies (e.g. SLE, T1D, psoriasis, Grave’s disease, IBD, MS (97)). Here, CD8A is linked to inflammatory bowel disease.