Pathogenic in animal models of systemic autoimmunity (64). However, clinical anti-IFN-γ treatment does not seem to improve either SLE (65) or Chron’s disease (66) (but cohorts were small). Pleiotropic role in experimental arthritis (67) Plays pleiotropic role in infection (69) and cancer (70). The gene discussed is IFNG; the disease is arthritic joint disease.