On the myeloid axis, scATAC-seq resolves macrophage continua from inflammatory to immunoregulatory states; in tumor-proximal macrophages, decreased IRF/STAT motif activity at antigen-presentation modules coexists with enhanced accessibility at enhancers controlling ARG1, IL10, and TGFB1, consistent with impaired cross-priming and active T-cell suppression (56–58). This evidence concerns the gene SOAT1 and neoplasm.