Elevated expression of Tn/STn antigens is associated with increased tumor invasiveness, metastasis, and poor prognosis, highlighting their potential as both diagnostic markers and therapeutic targets in cancer (8–10).Furthermore, the activity of T synthase is entirely dependent on its molecular chaperone, COSMC, which is crucial for the correct folding of T synthase in the ER, thereby ensuring its catalytic function. The gene discussed is C1GALT1C1; the disease is cancer.