C1GALT1C1 and neoplasm: Multiple studies were conducted to reveal the dual regulatory effects of Tn antigen accumulation on tumor biological behavior through gene editing models, and CRISPR/Cas9-mediated knockdown of the C1GALT1C1 gene has been reported to alter the cell-intrinsic properties of tumor cells, influencing genes related to MAPK signaling, cell migration, angiogenesis, and immunomodulation (87).