Initially, by accessing various online databases, such as GEPIA (http://gepia.cancer-pku.cn/), TNMplot (https://tnmplot.com), and Kaplan-Meier plotter (http://kmplot.com), we analyzed the expression level and prognosis of SULT1B1 in ESCC patients. Here, SULT1B1 is linked to esophageal squamous cell carcinoma.