This was supported by Bester et al., who demonstrated that IL-1β, IL-6, and IL-8 (proinflammatory cytokines) promote whole-blood hypercoagulability and alter erythrocyte membrane structure; IL-8, in particular, induced visible membrane changes and initiated eryptosis (Bester and Pretorius, 2016). Here, CXCL8 is linked to thrombophilia.