Moreover, OX1R/CCK1R heterodimers inhibit the migration of HT-29 cells stimulated by dual agonists, suggesting that OX1R/CCK1R heterodimerization plays an anti-migratory role in human colon cancer cells, providing new targets for cell anti-migration in the treatment of cancer. Here, HCRTR1 is linked to malignant colon neoplasm.