These results indicate that after the formation of heterodimers between OX1R and GHSR1a, ghrelin biases toward Gαs signaling, promoting the upregulation of the Gαs-cAMP-cAMP response element signaling pathway and the increase in neuroblastoma cell proliferation, possibly exerting a neuroprotective effect. Here, HCRTR1 is linked to neuroblastoma.