The potential of GAL (1–15) as an adjunct to selective serotonin reuptake inhibitors (SSRIs) was explored, showing that GAL (1–15) potentiated fluoxetine (FLX) antidepressant effects and mitigated memory impairment, involving 5-HT1AR in the hippocampus and prefrontal cortex (PFC) (Flores-Burgess et al., 2017; Flores-Burgess et al., 2019). This evidence concerns the gene GAL and memory impairment.