NFE2L2 and familial pancreatic carcinoma: Meanwhile, upregulation of Nrf2 was observed in various tumors, including breast, ovarian, prostate, skin, lung, and pancreatic cancers (Gorrini et al., 2013; Kong and Chandel, 2018),The catalytic activity and protein stability of ALDH1A1 are highly dependent on reduced GSH (Wang et al., 2017), further supporting that the two-drug combination can affect the glutathione metabolic pathway.