The chemokine CXCL12, which is highly expressed in metastatic niches, including the bone marrow, liver, and the brain, has its receptor CXCR4 that engages in a signaling cascade that stimulates tumor proliferation, survival, and resistance to apoptosis through PI3K/AKT, MAPK/ERK, and JAK/STAT pathways (Mousavi, 2020). This evidence concerns the gene AKT1 and neoplasm.