HIF1A and neoplasm: Moreover, hypoxic conditions in TME stimulate tumor aggressiveness driven by CXCR4, due to hypoxia-inducible factor 1 alpha (HIF1α) stabilization of CXCR4 expression and tumor cell survival in nutrient deprivations (Miranda-Galvis and Teng, 2020; Emami Nejad et al., 2021).