Furthermore, CXCR4 helps in immunosuppression by driving regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs), and tumor-associated macrophage (TAMs) into the tumor microenvironment (TME) along with each other to create an immunosuppressive TME (Hussain et al., 2025) and at the same time neutralize chemotherapy, radiotherapy, and ICIs therapies (Barnestein et al., 2022; Wu et al., 2025). The gene discussed is CXCR4; the disease is neoplasm.