Individuals with CXCR4 overexpression have reduced overall survival (OS) and disease-free survival (DFS), and it seems that the high CXCR4 expression has a negative influence, especially in stage III and IV lung cancer, correlated with metastasis to the brain, liver, and bone (Franco et al., 2012; Pulido et al., 2017). Here, CXCR4 is linked to lung cancer.