Liu et al. demonstrated that hypoxia enhances CXCR4-mediated metastasis via HIF-1α and HIF-2α activation, promoting cancer cell adhesion, movement, and invasion in response to CXCL12, indicating that targeting CXCR4 alongside hypoxia pathways may provide novel therapeutic strategies (Liu et al., 2006). This evidence concerns the gene HIF1A and cancer.