Wald et al. demonstrated that CXCL12-expressing cancer-associated fibroblasts (CAFs) facilitate cancer progression by supporting CXCR4+ cancer cell survival, reinforcing the significance of targeting the CXCR4/CXCL12 to disrupt tumor-stroma interactions (Wald et al., 2011). The gene discussed is CXCL12; the disease is neoplasm.