Similarly, Bi et al. found a strong correlation between lymph node metastasis in NSCLC and the expression of VEGF-C and CXCR4, further validating the role of CXCR4 as a predictive marker for disease progression and therapeutic response (Bi et al., 2017). The gene discussed is CXCR4; the disease is metastatic malignant neoplasm in the lymph nodes.