These core pathways included PI3K-AKT, NF-κB, and JAK-STAT signaling, all of which have been previously implicated in the pathogenesis and treatment of cirrhosis (Wei et al., 2018; Jiang et al., 2023; Zhang et al., 2023; Huang et al., 2021). This evidence concerns the gene AKT1 and Cirrhosis.