After excluding patients with a substantial amount of missing data, the final dataset comprised the following 31 predictor variables: Age, Gender, BMI, Liver Cirrhosis (LC), Family history, HBsAg (0W), HBsAg (24W), HBsAg_desc, HBeAg(0W), HBeAg(24W), HBeAg_desc, HBeAb (0W), HBeAb (24W), HBeAb_desc, HBcAb (0W), HBcAb (24W), HBcAb_desc, ALT (0W), ALT (24W), AST (0W), AST (24W), GGT (0W), GGT (24W), TBIL (0W), TBIL (24W), DBIL (0W), DBIL (24W), ALP (0W), ALP (24W), and PLT (0W),PLT (24W) (Supplementary Table S1). The gene discussed is GPT; the disease is cirrhosis of liver.