Eleven proteins EZR, ADGRG2, CPA2, SRC, THBS4, NMNAT1, P4HB, IL-1ra, IL-6, NCAN, ANGPT1, and PTN were upregulated in DM1, while three proteins IGFBP6, CDH1, and MET were downregulated in DM1 compared to HCs (Figure 6). This evidence concerns the gene IGFBP6 and myotonic dystrophy type 1.