Eleven proteins EZR, ADGRG2, CPA2, SRC, THBS4, NMNAT1, P4HB, IL-1ra, IL-6, NCAN, ANGPT1, and PTN were upregulated in DM1, while three proteins IGFBP6, CDH1, and MET were downregulated in DM1 compared to HCs (Figure 6). The gene discussed is THBS4; the disease is myotonic dystrophy type 1.