THBS4 and spinal muscular atrophy: Düzenli et al. (2022) provide evidence for TSP4’s role in neuropathic pain development, suggesting that its blockade could be a promising therapeutic approach. Additionally, THBS4 is involved in cell adhesion and cytoskeletal organization (Lawler et al., 1993) and has been reported as a potential biomarker for spinal muscular atrophy (SMA), with reduced levels found in pediatric SMA patients (Dobelmann et al., 2024).