AKT1 and glioblastoma: Furthermore, CKAP4’s role in regulating transcription factors like FOXM1, which are involved in DNA repair through AKT/ERK signaling pathways associated with somatic polynucleotide repeat expansion CKAP4-mediated activation of FOXM1 via phosphorylation pathways regulates malignant behavior of glioblastoma cells (Xu et al., 2023), supports that CKAP4 dysregulation may underlie the cellular dysfunction observed in DM1.