Furthermore, CKAP4’s role in regulating transcription factors like FOXM1, which are involved in DNA repair through AKT/ERK signaling pathways associated with somatic polynucleotide repeat expansion CKAP4-mediated activation of FOXM1 via phosphorylation pathways regulates malignant behavior of glioblastoma cells (Xu et al., 2023), supports that CKAP4 dysregulation may underlie the cellular dysfunction observed in DM1. This evidence concerns the gene FOXM1 and glioblastoma.