These findings align with prior research highlighting the role of cytoskeletal proteins in neuronal function and their dysregulation in neurodegenerative disorders such as Friedreich’s ataxia, spinocerebellar ataxia type 5, Alzheimer’s disease, and Parkinson’s disease (Zhang et al., 2015; Bamburg and Bernstein, 2016; Piermarini et al., 2016; Avery et al., 2017; Del Rey et al., 2018; Muñoz-Lasso et al., 2020). Here, DNM2 is linked to early-onset autosomal dominant Alzheimer disease.