We have previously shown that PBMC circadian-related core clock proteins, such as CLOCK, phosphorylated BMAL1, PER2 and CRY1 (among others), are diminished in overweight subjects with type 2 diabetes, and that these alterations are associated with increased inflammatory parameters and enhanced leukocyte-endothelial cell interactions (29). Here, CLOCK is linked to type 2 diabetes mellitus.