Recent studies showed missense variants is frequently associated with epilepsy in established genes of neurodevelopmental disorders, such as several genes reported in recent studies such as ACTB (51), APC2 (52), BCOR (53), CCDC22 (54), DLG3 (55), EP400 (56) FRMPD4 (57), GABRA1 (58), SZT2 (59), TANC2 (60), and KCNK4 (61). This evidence concerns the gene ACTB and neurodevelopmental disorder.