Recent studies showed missense variants is frequently associated with epilepsy in established genes of neurodevelopmental disorders, such as several genes reported in recent studies such as ACTB (51), APC2 (52), BCOR (53), CCDC22 (54), DLG3 (55), EP400 (56) FRMPD4 (57), GABRA1 (58), SZT2 (59), TANC2 (60), and KCNK4 (61). The gene discussed is ACTB; the disease is epilepsy.