Recent studies showed missense variants is frequently associated with epilepsy in established genes of neurodevelopmental disorders, such as several genes reported in recent studies such as ACTB (51), APC2 (52), BCOR (53), CCDC22 (54), DLG3 (55), EP400 (56) FRMPD4 (57), GABRA1 (58), SZT2 (59), TANC2 (60), and KCNK4 (61). This evidence concerns the gene APC2 and neurodevelopmental disorder.