This network Meta-Analysis showed that CRP (MD = 7.58, 95% CI: 2.48–14.09) and IL-6 (MD = 6.98, 95% CI: 2.75–11.44) were more significantly elevated in the acute phase in CVT patients than in IS patients, suggesting they could serve as key inflammatory markers for differentiating the two conditions. The gene discussed is IL6; the disease is congenital vertical talus.