By intersecting the upregulated genes in HCC‐derived organoids (vs. healthy liver organoids), the dedifferentiation‐associated genes from the CytoTRACE database18 and the abovementioned 23 oncofetal genes, we identified five key oncofetal genes: ASCL4, DUSP9, MCM2, PEG10 and ROBO1 (Figure 3A). Here, ROBO1 is linked to hepatocellular carcinoma.