Herein, we found that treatment of PC3 and DU145 cell lines with the PI3K inhibitor BEZ235 successfully abolished the pro‐tumor effects of adipocytes, further supporting the potential role of Akt signaling in promoting the obesity‐mediated PCa evolution, as previously highlighted in melanoma and colorectal, ovarian and breast carcinoma [34, 38, 39]. Here, AKT1 is linked to melanoma.