Then, we demonstrated that the EVs released from PCa cells triggered lipolysis in adipocytes, which exhibited decreased lipid content and enhanced FFA and glycerol secretion; in particular, these changes were accompanied by the inhibition of G0S2, upregulation of ATGL and activation of the cAMP/PKA/HSL signaling pathway. The gene discussed is PNPLA2; the disease is posterior cortical atrophy.