Herein, we demonstrated that PCa EVs can trigger lipolysis in 3T3‐L1 adipose cells, by downregulating G0/G1 switch protein 2 (G0S2), inducing adipose triglyceride lipase (ATGL) expression and activating the cyclic AMP (cAMP)/protein kinase A (PKA)/hormone‐sensitive lipase (HSL) signaling pathway. Here, LIPE is linked to posterior cortical atrophy.