ZNHIT3 and PEHO-like syndrome: ,31 The three known PEHO syndrome-associated ZNHIT3 missense variants p.Cys14Arg, p.Cys14Phe, and p.Ser31Leu allow embryonic development by destabilizing the ZNHIT3 protein leading to decreased ZNHIT3 steady-state levels in yeast and human cell culture.14