USP3 and osteoarthritis: Jia et al demonstrated that digoxin attenuates osteoarthritis-associated inflammatory processes by inhibitory modulation of the microRNA-146b-5p/ubiquitin-specific peptidase 3 & SRY-box transcription factor 5 (miR-146b-5p/Usp3/Sox5) molecular axis in M1 macrophage-derived exosomal populations.