An integrated signaling model further demonstrated how PTM-mediated suppression of the EGFR-RAS axis, along with activation of the p38 and p53 pathways, collectively contributes to shaping the aging phenotype in CRC.<h4>Conclusion</h4>This study presents the first integrative network map of aging regulation in CRC based on multiple PTMs. Here, TP53 is linked to colorectal carcinoma.