NFE2L2 and Hyperglycemia: In endothelial cells exposed to hyperglycemia, NF-κB activation induced persistent up-regulation of miR-27a-3p, which suppressed NRF2, reduced NO production, increased ROS generation and TGF-β signaling, and triggered endothelial-to-mesenchymal transition (EndMT), driving perivascular fibrosis and cardiac dysfunction [138].