DNM1L and myocardial ischemia: In myocardial ischemia–reperfusion–induced diabetic mice, inhibition of Drp1 with Mdivi-1 at 1.2 mg/kg 15 minutes prior to reperfusion significantly suppressed mitochondrial translocation of Drp1, limited mitochondrial fission, and enhanced both mitochondrial and cardiac function, while concurrently reducing infarct size, cardiomyocyte apoptosis, oxidative stress, and serum troponin I and LDH [176].