Hyperglycemia has also been demonstrated to disrupt mitochondrial dynamics by promoting Drp1 phosphorylation at Ser616 and reducing its phosphorylation at Ser637, thereby shifting the balance toward excessive mitochondrial fission and consequent mitochondrial dysfunction, which contributes to the progression of cardiomyocyte hypertrophy in diabetic rats [74]. The gene discussed is DNM1L; the disease is Hyperglycemia.