In a rat model of STZ- induced T2DM, Aminoguanidine significantly reduced cardiac fibrosis, lowered expression of α-smooth muscle actin, NOX4, and Nos2, and attenuated collagen type I deposition via suppression of ERK1/2 and SMAD2/3 signaling through the AGE/RAGE pathway [156]. The gene discussed is AGER; the disease is type 2 diabetes mellitus.