MFN2 and diabetic cardiomyopathy: Mechanistically, USP28 directly interacts with PPARα, deubiquitinates and stabilizes it at Lys152, promoting transcription of Mfn2 to restore mitochondrial fusion, which mitigates ROS production, reduces fibrosis, and improves both systolic and diastolic function in models of diabetic cardiomyopathy [76].