As a result of this, ISO-injured mice presented with a significant reduction in LV MMP-13/TIMP-1 (by ~ 60%; Fig. 6G), MMP-9/TIMP-1 (by ~ 55%; Fig. 6H) and MMP-2/TIMP-2 (by ~ 65%; Fig. 6I) ratios at day 14 post-injury, in line with the increased LV fibrosis in these mice (Fig. 4B). This evidence concerns the gene TIMP2 and fibrosis.