UBE3A and Anxiety: “Anxiety” has been described as a “frequent” clinical feature in AS through multiple rounds of consensus reporting [3] and almost all caregivers report some behaviors interpreted as anxiety-related distress [5, 6], although these concerns tend to be reported more frequently in persons with AS with the less common non-deletion subtypes of AS (Uniparental disomy, imprinting defects, UBE3A point mutations) [7].